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Neurogenic mechanisms in bladder and bowel ageing

Ranson, Richard N. and Saffrey, M. Jill (2015). Neurogenic mechanisms in bladder and bowel ageing. Biogerontology, 16(2) pp. 265–284.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1007/s10522-015-9554-3
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Abstract

The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the quality of life of the elderly. Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden. Understanding how these changes occur is thus a major priority in biogerontology. The functions of the bladder and terminal bowel are regulated by complex neuronal networks. In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence. In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly.

Item Type: Journal Item
Copyright Holders: 2015 The Authors
ISSN: 1573-6768
Project Funding Details:
Funded Project NameProject IDFunding Body
Integrated analysis of the impact of age-associated neuronal and enteroendocrine changes on normal bowel functionsBB/G015988/1BBSRC
Keywords: neuroscience; ageing; bladder; bowel; anal sphincter; incontinence; constipation; autonomic nervous system; enteric nervous system
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 42168
Depositing User: Jill Saffrey
Date Deposited: 26 Feb 2015 10:31
Last Modified: 15 May 2017 20:04
URI: http://oro.open.ac.uk/id/eprint/42168
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