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Effect of the solvent on recognition properties of molecularly imprinted polymer specific for ochratoxin A

Turner, Nicholas W.; Piletska, Elena V.; Karim, Khalku; Whitcombe, Michael; Malecha, Michael; Magan, Naresh; Baggiani, Claudio and Piletsky, Sergey A. (2004). Effect of the solvent on recognition properties of molecularly imprinted polymer specific for ochratoxin A. Biosensors and Bioelectronics, 20(6) pp. 1060–1067.

DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bios.2004.06.052
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Abstract

A molecularly imprinted polymer specific for the mycotoxin ochratoxin A has been synthesised using a non-covalent approach. The polymer has shown an excellent affinity and specificity for the target template in aqueous solutions. The binding experiments, NMR study and molecular modelling have proven that the template recognition by polymer originates from the shape complementarity of binding sites. The binding mechanism is critically depended on factors that affect the polymer conformation. Thus the variation in buffer concentration, pH and presence of organic solvent, which affect the polymer swelling or shrinking, had a profound effect on the polymer recognition properties.

Item Type: Journal Item
Copyright Holders: 2004 Elsevier B.V.
ISSN: 1873-4235
Extra Information: Special issue on Synthetic Receptors
Keywords: molecular imprinting; polymer conformation; ochratoxin A; recognition; sensor; SPE
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 41997
Depositing User: Nicholas Turner
Date Deposited: 12 Feb 2015 11:57
Last Modified: 07 Dec 2018 10:28
URI: http://oro.open.ac.uk/id/eprint/41997
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