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From 3D to 2D: A review of the molecular imprinting of proteins

Turner, Nicholas W.; Jeans, Christopher W.; Brain, Keieth R.; Allender, Christopher J.; Hlady, Vladimir and Britt, David W. (2006). From 3D to 2D: A review of the molecular imprinting of proteins. Biotechnology Progress, 22(6) pp. 1474–1489.

URL: http://onlinelibrary.wiley.com/doi/10.1021/bp06012...
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Abstract

Molecular imprinting is a generic technology that allows for the introduction of sites of specific molecular affinity into otherwise homogeneous polymeric matrices. Commonly this technique has been shown to be effective when targeting small molecules of molecular weight <1500, while extending the technique to larger molecules such as proteins has proven difficult. A number of key inherent problems in protein imprinting have been identified, including permanent entrapment, poor mass transfer, denaturation, and heterogeneity in binding pocket affinity, which have been addressed using a variety of approaches. This review focuses on protein imprinting in its various forms, ranging from conventional bulk techniques to novel thin film and monolayer surface imprinting approaches.

Item Type: Journal Item
Copyright Holders: 2006 American Institute of Chemical Engineers (AIChE)
ISSN: 1520-6033
Project Funding Details:
Funded Project NameProject IDFunding Body
Not Set2005-35603-15829National Research Initiative of the USDA Cooperative State Research, Education and Extension Service
Not Set0404262NSF-NER Division of Bioengineering & Environmental Systems
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 41992
Depositing User: Nicholas Turner
Date Deposited: 12 Feb 2015 11:27
Last Modified: 01 May 2019 13:16
URI: http://oro.open.ac.uk/id/eprint/41992
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