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Influence of surface-imprinted nanoparticles on trypsin activity

Guerreiro, António; Poma, Alessandro; Karim, Kal; Moczko, Ewa; Takarada, Jessica; de Vargas-Sansalvador, Isabel Perez; Turner, Nicholas; Piletska, Elena; de Magalhães, Cristiana Schmidt; Glazova, Natalia; Serkova, Anastasia; Omelianova, Aleksandra and Piletsky, Sergey (2014). Influence of surface-imprinted nanoparticles on trypsin activity. Advanced Healthcare Materials, 3(9) pp. 1426–1429.

DOI (Digital Object Identifier) Link: https://doi.org/10.1002/adhm.201300634
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Abstract

[T]he modulation of enzyme activity is presented by protein-imprinted nanoparticles produced using a solid-phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.

Item Type: Journal Item
Copyright Holders: 2014 Wiley-VCH Verlag
ISSN: 2192-2659
Keywords: enzyme inhibition; molecularly imprinted polymers; molecular recognition; nanoparticles; supramolecular chemistry
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 41991
Depositing User: Nicholas Turner
Date Deposited: 02 Feb 2015 10:49
Last Modified: 07 Dec 2018 10:28
URI: http://oro.open.ac.uk/id/eprint/41991
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