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Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles

Poma, Alessandro; Brahmbhatt, Heli; Pendergraff, Hannah M.; Watts, Jonathan K. and Turner, Nicholas W. (2015). Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4) pp. 750–758.

DOI (Digital Object Identifier) Link: https://doi.org/10.1002/adma.201404235
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Abstract

A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.

Item Type: Journal Item
Copyright Holders: 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN: 1521-4095
Keywords: aptamers; cocaine; molecularly imprinted polymers; nanoparticles; solid-phase synthesis
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Item ID: 41986
Depositing User: Nicholas Turner
Date Deposited: 04 Feb 2015 14:55
Last Modified: 17 Nov 2016 14:56
URI: http://oro.open.ac.uk/id/eprint/41986
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