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A mathematical framework for nerve regeneration in implantable conduits

Evans, O. R.; Phillips, J. B. and Shipley, R. J. (2014). A mathematical framework for nerve regeneration in implantable conduits. In: Conference Book, p. 106.

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Abstract

Matching the performance of autografts with engineered scaffolds remains a challenge in peripheral nerve repair. A combination of 3D biomimetic architecture interspersed with 2D surfaces has been hypothesized to be an ideal environment for neurite regeneration. However, the problem of how best to arrange material within a conduit is an open one. Optimizing material parameters such as density, cross-sectional geometry and spatial distribution would require an extensive programme of experimental testing. By contrast, developing a modelling framework that is capable of testing key parameters may accelerate the design process, and reduce the dependency on animal testing.

Item Type: Conference or Workshop Item
Copyright Holders: 2014 The Authors
Extra Information: With UK Regenerative Medicine Platform Hubs: Joint Annual Science and Industry Meeting
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
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Item ID: 41313
Depositing User: James Phillips
Date Deposited: 11 Nov 2014 09:33
Last Modified: 04 Oct 2016 20:32
URI: http://oro.open.ac.uk/id/eprint/41313
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