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Glia selectively approach synapses on thin dendritic spines

Medvedev, Nikolay; Popov, Victor; Henneberger, Christian; Kraev, Igor; Rusakov, Dmitri and Stewart, Michael (2014). Glia selectively approach synapses on thin dendritic spines. Philosophical Transactions of the Royal Society B, 369(1654), article no. 20140047.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1098/rstb.2014.0047
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Abstract

This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine PSDs are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines).

Item Type: Journal Item
Copyright Holders: 2014 The Authors
ISSN: 1471-2970
Project Funding Details:
Funded Project NameProject IDFunding Body
The role of multi-innervated dendritic spines in memory formation in old ageBB/J021687/1BBSRC
Extra Information: 7 pp.
Keywords: glia protection; synapses; thin spines
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Centre for Research in Computing (CRC)
Related URLs:
Item ID: 40717
Depositing User: Michael Stewart
Date Deposited: 14 Aug 2014 08:02
Last Modified: 10 Dec 2018 22:02
URI: http://oro.open.ac.uk/id/eprint/40717
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