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Glia selectively approach synapses on thin dendritic spines

Medvedev, Nikolay; Popov, Victor; Henneberger, Christian; Kraev, Igor; Rusakov, Dmitri and Stewart, Michael (2014). Glia selectively approach synapses on thin dendritic spines. Philosophical Transactions of the Royal Society B, 369(1654), article no. 20140047.

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This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine PSDs are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines).

Item Type: Journal Item
Copyright Holders: 2014 The Authors
ISSN: 1471-2970
Project Funding Details:
Funded Project NameProject IDFunding Body
The role of multi-innervated dendritic spines in memory formation in old ageBB/J021687/1BBSRC
Extra Information: 7 pp.
Keywords: glia protection; synapses; thin spines
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Research Group: Centre for Research in Computing (CRC)
Related URLs:
Item ID: 40717
Depositing User: Michael Stewart
Date Deposited: 14 Aug 2014 08:02
Last Modified: 10 Dec 2018 22:02
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