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Giant nuclei is essential in the cell cycle transition from meiosis to mitosis

Renault, Andrew D.; Zhang, Xiao-Hua; Alphey, Luke S.; Frenz, Lisa M.; Glover, David M.; Saunders, Robert D. C. and Axton, J. Myles (2003). Giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Development, 130(13) pp. 2997–3005.

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At the transition from meiosis to cleavage mitoses, Drosophila requires the cell cycle regulators encoded by the genes, giant nuclei (gnu), plutonium (plu) and pan gu (png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

Item Type: Journal Article
ISSN: 0950-1991
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetUK Medical Research Council (MRC)
Keywords: Drosophila melanogaster; Mitosis; DNA replication; Fertilization; Oogenesis; Protein phosphatase 1
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 4035
Depositing User: Robert Saunders
Date Deposited: 06 Jul 2006
Last Modified: 16 Jan 2016 07:30
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