Clemente, A.; Domingos, A.; Grancho, A. P.; Iley, James; Moreira, R.; Neres, J.; Palma, N.; Santana, A. B. and Valente, E.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/S0960-894X(01)00131-7|
|Google Scholar:||Look up in Google Scholar|
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
|Item Type:||Journal Article|
|Keywords:||HLE; inhibitor; beta-lactam; acyloxymethyl|
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
|Depositing User:||James Iley|
|Date Deposited:||06 Jul 2006|
|Last Modified:||02 Aug 2016 12:57|
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