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Clemente, A.; Domingos, A.; Grancho, A. P.; Iley, James; Moreira, R.; Neres, J.; Palma, N.; Santana, A. B. and Valente, E.
(2001).
DOI: https://doi.org/10.1016/S0960-894X(01)00131-7
Abstract
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
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About
- Item ORO ID
- 4018
- Item Type
- Journal Item
- ISSN
- 0960-894X
- Keywords
- HLE; inhibitor; beta-lactam; acyloxymethyl
- Academic Unit or School
-
Other Departments > Other Departments
Other Departments - Depositing User
- James Iley