Clemente, A.; Domingos, A.; Grancho, A. P.; Iley, James; Moreira, R.; Neres, J.; Palma, N.; Santana, A. B. and Valente, E.
(2001).
| DOI (Digital Object Identifier) Link: | http://doi.org/10.1016/S0960-894X(01)00131-7 |
|---|---|
| Google Scholar: | Look up in Google Scholar |
Abstract
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
| Item Type: | Journal Article |
|---|---|
| ISSN: | 0960-894X |
| Keywords: | HLE; inhibitor; beta-lactam; acyloxymethyl |
| Academic Unit/Department: | Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences Faculty of Science, Technology, Engineering and Mathematics (STEM) |
| Item ID: | 4018 |
| Depositing User: | James Iley |
| Date Deposited: | 06 Jul 2006 |
| Last Modified: | 02 Aug 2016 12:57 |
| URI: | http://oro.open.ac.uk/id/eprint/4018 |
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