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Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

Clemente, A.; Domingos, A.; Grancho, A. P.; Iley, James; Moreira, R.; Neres, J.; Palma, N.; Santana, A. B. and Valente, E. (2001). Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors. Bioorganic and Medicinal Chemistry Letters, 11(8) pp. 1065–1068.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S0960-894X(01)00131-7
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Abstract

A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.

Item Type: Journal Article
ISSN: 0960-894X
Keywords: HLE; inhibitor; beta-lactam; acyloxymethyl
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Item ID: 4018
Depositing User: James Iley
Date Deposited: 06 Jul 2006
Last Modified: 02 Dec 2010 19:50
URI: http://oro.open.ac.uk/id/eprint/4018
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