Lopes, Francisca; Capela, Rita; Gonçaves, Jose O.; Horton, Peter N.; Hursthouse, Michael B.; Iley, Jim; Casimiro, Catarina M.; Bom, Joana and Moreira, Rui (2004).
| DOI (Digital Object Identifier) Link: | http://dx.doi.org/doi:10.1016/j.tetlet.2004.08.093 |
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| Google Scholar: | Look up in Google Scholar |
Abstract
Novel N-Mannich base-type derivatives of the antimalarial drug amodiaquine were synthesised by reaction with tertiary
N-chloromethylamides. With the exception of the derivative of ethyl hippurate, all the so-formed (1-amidomethyl-1H-quinolin-4-ylidene)arylamines displayed high chemical and enzymatic stability. These compounds displayed antimalarial activity against the multi-drug resistant Plasmodium falciparum strain Dd2 (IC50 values 15–31nM) and demonstrated no significant loss in activity compared
to amodiaquine (IC50 30nM).
| Item Type: | Journal Article |
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| ISSN: | 0040-4039 |
| Keywords: | amodiaquine; malaria; Mannich basel; Amodiaquine; Amidomethylation; antimalarial |
| Academic Unit/Department: | Science > Chemistry and Analytical Sciences |
| ID Code: | 3989 |
| Deposited By: | James Iley |
| Deposited On: | 04 Jul 2006 |
| Last Modified: | 02 Jul 2008 23:44 |
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