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Diversity of astroglial functions alludes to subcellular specialisation

Rusakov, Dimitri A.; Bard, Lucie; Stewart, Michael G. and Henneberger, Christian (2014). Diversity of astroglial functions alludes to subcellular specialisation. Trends in Neuroscience, 1043

URL: http://dx.doi.org/10.1016/j.tins.2014.02.008
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Abstract

Rapid signal exchange between astroglia and neurons has emerged as an essential element of neural circuits of the brain. However, the increasing variety of mechanisms contributing to this signalling appears to be facing a conceptual stalemate. The communication medium of astroglia involves intracellular [Ca2+] waves, which until recently have been associated with slow, global [Ca2+] rises. How such a uniform trigger could handle fast and iverse molecular messages remains unexplained. Recent studies have, however, revealed a variety of apparently independent Ca2+ activities within individual astrocytic compartments, also indicating the prevalence of subcellular segregation for some signalling mechanisms. These signs of intracellular compartmentalisation might provide the key to the multitude of adaptive roles played by astroglia.

Item Type: Journal Item
Copyright Holders: 2014 Elsevier
Project Funding Details:
Funded Project NameProject IDFunding Body
High resolution 3-D reconstructions from brain tissue via Field Emission scanning electron microscopy in back scattered electron (BSE) imaging modeBB/I020330/1BBSRC (Biotechnology and Biological Sciences Research Council)
The Role of Multi-innervated Dendritic Spines in Memory Formation in AgeingBB/J021687/1BBSRC (Biotechnology and Biological Sciences Research Council)
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Related URLs:
Item ID: 39739
Depositing User: Michael Stewart
Date Deposited: 17 Mar 2014 08:35
Last Modified: 07 Dec 2018 10:22
URI: http://oro.open.ac.uk/id/eprint/39739
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