Radiosensitization of DNA in presence of Pt(II)-based compounds

Smialek, Malgorzata A.; Ptasińska, Sylwia; Gow, Jason; DaPieve, Chiara and Mason, Nigel J. (2014). Radiosensitization of DNA in presence of Pt(II)-based compounds. European Physical Journal D - Atomic, Molecular and Optical Physics, 68, article no. 85.

DOI: https://doi.org/10.1140/epjd/e2014-40846-7

Abstract

X-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results were examined against a common cancer chemotherapy drug cis-diamminedichloroplatinum (II). It was found that platinum (II) bromide can greatly increase the levels of single- and double-strand break formation observed in the irradiated samples with respect to the samples containing platinum as a radiosensitizer only, possessing very little chemotherapeutic activity. The suggested drugs exhibit much higher level of radiosensitivity than widely used cisplatin and thus may be good candidates for cancer treatment.

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