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Study on synthesis and fluorescence spectra of 5-bromor-4-thio-2′-deoxyuridine labeled with monobromobimanes fluorescein

Yin, Hong-yan; Zhang, Xiao-hui and Xu, Yao-zhong (2011). Study on synthesis and fluorescence spectra of 5-bromor-4-thio-2′-deoxyuridine labeled with monobromobimanes fluorescein. Journal of Molecular Science, 27(6) pp. 397–401.

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Document Language: Chinese (Simplified) [簡體字]
URL: http://en.cnki.com.cn/Article_en/CJFDTotal-FZKB201...
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Abstract

5-bromor-4-thio-2′-Deoxyuridine was synthesized by 1,2,4-triazole and thio-acetic acid from 5-bromor-2′-Deoxyuridine in mild condition,and then was carried out electrophilic reaction with monobromobimanes (mBBR)at 4 position sulphur,5-bromor-4-thio-2′-Deoxyuridine labeled with monobromobimanes (mBBR) was synthesized.Their structures were analyzed and characterized using 1 H NMR,MS,UV and fluorescence spectra.It can produce high fluorescence characteristics of the compound 5-bromo-4-thiodiamine-2′-deoxyuridine,which provides a body of 5-bromo-4-thio-2′-deoxyuridine-sentive detection method.

Item Type: Journal Item
Copyright Holders: 2011 China Academic Journal Electronic Publishing House
ISSN: 1000-9035
Extra Information: Text in Simplified Chinese
Keywords: 5-bromo-2'deoxyuridine; monobromobimane, fluorescence; synthesis
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 39652
Depositing User: Yao Xu
Date Deposited: 07 Mar 2014 12:04
Last Modified: 13 Dec 2018 19:53
URI: http://oro.open.ac.uk/id/eprint/39652
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