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Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia.

Reuter, B.; Rodemer, C.; Grudzenski, S.; Couraud, P.-O.; Weksler, B.; Romero, Ignacio A; Meairs, S.; Bugert, P.; Hennerici, M. G and Fatar, M. (2013). Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia. Cerebrovascular Diseases, 35(6) pp. 514–520.

DOI (Digital Object Identifier) Link: https://doi.org/10.1159/000350731
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Abstract

The objective of our study was to determine the contribution of human BMECs to the MMP metabolism under in vitro OGD conditions simulating ischemic stroke. Our results suggest that human BMECs switch to a proinflammatory state by means of an enhanced production of MMP-2, attenuated release of TIMP-1, and unaffected production of TIMP-2. Thus, human BMECs might participate in the MMP-mediated BBB breakdown during ischemic stroke. However, our data does not support human BMECs to be a source of MMP-9.

Item Type: Journal Item
Copyright Holders: 2013 Karger Publishers
ISSN: 1421-9786
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 39566
Depositing User: Ignacio A Romero
Date Deposited: 25 Feb 2014 14:22
Last Modified: 07 Dec 2018 10:21
URI: http://oro.open.ac.uk/id/eprint/39566
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