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MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis.

Reijerkerk, Arie; Lopez-Ramirez, M. Alejandro; van Het Hof, Bert; Drexhage, Joost A. R.; Kamphuis, Wouter W.; Kooij, Gijs; Vos, Joost B.; van der Pouw Kraan, Tineke C. T. M.; van Zonneveld, Anton J.; Horrevoets, Anton J.; Prat, Alexandre; Romero, Ignacio A and de Vries, Helga E. (2013). MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. The Journal of Neuroscience, 33(16) pp. 6857–6863.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1523/JNEUROSCI.3965-12.2013
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Abstract

Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.

Item Type: Journal Item
Copyright Holders: 2013 the authors
ISSN: 1529-2401
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 39563
Depositing User: Ignacio A Romero
Date Deposited: 25 Feb 2014 13:53
Last Modified: 08 Dec 2018 04:10
URI: http://oro.open.ac.uk/id/eprint/39563
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