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Building stable anisotropic tissues using cellular collagen gels

Phillips, James B. (2014). Building stable anisotropic tissues using cellular collagen gels. Organogenesis, 10(1) pp. 6–8.

DOI (Digital Object Identifier) Link: https://doi.org/10.4161/org.27487
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Abstract

Combining cellular self-alignment within tethered collagen gels with stabilization through subsequent removal of interstitial fluid has yielded a new process for the fabrication of aligned cellular biomaterials. This commentary discusses the generation of engineered neural tissue for peripheral nerve repair using this combination of techniques, providing additional insight into the rationale underpinning the approach. By describing the potential benefits of using cell and matrix interactions to organize 3D hydrogels that can be stabilized to form tissue-like constructs, the article aims to highlight the potential for the approach to be used in the generation of a wider range of functional replacement tissues.

Item Type: Journal Item
Copyright Holders: 2014 Landes Bioscience
ISSN: 1555-8592
Keywords: collagen; hydrogel; regenerative medicine; tissue engineering; nerve; anisotropy; Schwann cell; biomaterials; alignment
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 39499
Depositing User: James Phillips
Date Deposited: 11 Feb 2014 16:31
Last Modified: 04 Oct 2016 11:33
URI: http://oro.open.ac.uk/id/eprint/39499
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