Medical implantable devices for the controlled release of anti-TGF-beta1 in the repair of peripheral nerve injuries

Caneva Soumetz, F.; Giacomini, M.; Phillips, J.B.; Brown, R.A. and Ruggiero, C. (2004). Medical implantable devices for the controlled release of anti-TGF-beta1 in the repair of peripheral nerve injuries. In: X Mediterranean Conference on Medical and Biological Engineering (MEDICON and Health Telematics 2004), 31 Jul - 5 Aug 2004, Ischia, Italy.

URL: http://www.medicon2004.unina.it/program/GeneralPro...

Abstract

The development of novel bioartificial nerve grafts which release soluble therapeutic agents, shows great promises guiding the extension of the injured axons and optimizing and improving the degree and specificity of neural outgrowth. The TGF-â family cytokines are polypeptides involved in pathogenesis of neuropathies during nerve lesion. In particular, studies carried out on TGF-â1 have demonstrated its key-role as a humoral stimulus in scar formation. The use of neutralising antibodies to this pro-fibrotic factor, incorporated and released by medical devices, could be potentially useful to get improved results in nerve repair. The aim of this study was to characterise the uptake and release of antibodies, structurally no different from the anti-TGFâ1 specific ones, by innovative constructs based on the use of biodegradable and biocompatible compounds with which to support and improve peripheral nerve repair.

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