Wright, K.E.; Liniker, E; MacRobert, A.J.; Brown, R.A.; Saffrey, M.J. and Phillips, J.B.
Investigating the effect of photodynamic therapy on nerves using tissue engineered culture models.
In: Tissue & Cell Engineering Society 2006, 3-4 Jul 2006, Sheffield, UK.
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Introduction: Photodynamic therapy (PDT) shows potential as an effective treatment for prostate cancer. Clinical observations indicate that this approach causes fewer nerve damage related side-effects than conventional treatments. The aim here is to investigate the effect of PDT on nerve tissue using engineered 3-dimensional cell culture models. Initial experiments focussed on establishing photosensitiser localisation in neurones and Schwann cells, then developing a model for simulating nerve PDT in culture.
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