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DNA aptamers for in vivo molecular targeted imaging and therapy

Missailidis, Sotiris and Perkins, Alan (2005). DNA aptamers for in vivo molecular targeted imaging and therapy. Tumor Biology, 27(Suppl. 1, 2006) p. 22.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1159/000090902
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Abstract

Introduction: Molecular targeted therapeutics offers high target affinity, specificity and improved therapeutic
potential with reduced side effects. The traditional use of antibodies has presented problems associated with
production, purification, immunogenicity and size, whereas small peptides have reduced affinities and specificities. Aptamers can be generated rapidly against targets, showing a better tumour penetration, rapid uptake and clearance, thus providing effective vehicles for cytotoxic agents.

Item Type: Journal Article
ISSN: 1010-4283
Extra Information: Tumor Biology Supplement 1, 2006 - Cancer Research, Tumor Markers, Clinical Oncology
Keywords: aptamer; targeted radiopharmaceuticals; tumour imaging; cancer therapy
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3905
Depositing User: Sotiris Missailidis
Date Deposited: 04 Jul 2006
Last Modified: 10 Mar 2014 10:31
URI: http://oro.open.ac.uk/id/eprint/3905
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