Missailidis, Sotiris and Perkins, Alan
(2005).
DNA aptamers for in vivo molecular targeted imaging and therapy.
Tumor Biology, 27(Suppl. 1, 2006),
p. 22.
Abstract
Introduction: Molecular targeted therapeutics offers high target affinity, specificity and improved therapeutic
potential with reduced side effects. The traditional use of antibodies has presented problems associated with
production, purification, immunogenicity and size, whereas small peptides have reduced affinities and specificities. Aptamers can be generated rapidly against targets, showing a better tumour penetration, rapid uptake and clearance, thus providing effective vehicles for cytotoxic agents.
| Item Type: |
Journal Article
|
| ISSN: |
1010-4283 |
| Extra Information: |
Tumor Biology Supplement 1, 2006 - Cancer Research, Tumor Markers, Clinical Oncology
|
| Keywords: |
aptamer; targeted radiopharmaceuticals; tumour imaging; cancer therapy |
| Academic Unit/Department: |
Science > Life, Health and Chemical Sciences |
| Item ID: |
3905 |
| Depositing User: |
Sotiris Missailidis
|
| Date Deposited: |
04 Jul 2006 |
| Last Modified: |
02 Dec 2010 19:50 |
| URI: |
http://oro.open.ac.uk/id/eprint/3905 |
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