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Xu, Yao-Zhong; Zhang, Xiaohui; Wu, Hai-Chen; Massey, Andrew and Karran, Peter
(2004).
DOI: https://doi.org/10.1016/j.bmcl.2003.11.069
Abstract
4-Thio-5-bromo-2'-deoxyuridine (3a) is prepared from 5-bromo-2'-deoxyuridine (BrdU) and its key properties are explored. The thionucleoside (3a) can react readily with monobromobimane and produces high fluorescence. 3a has UV maximum absorption at 340 nm and can be incorporated into cellular DNA. The cells containing 3a become sensitive to UVA light, offering therapeutic potential for UVA-induced cell killing.
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About
- Item ORO ID
- 3835
- Item Type
- Journal Item
- ISSN
- 0960-894X
- Extra Information
- Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract.
- Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM) - Depositing User
- Yao Xu