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4-Thio-5-bromo-2′-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage

Xu, Yao-Zhong; Zhang, Xiaohui; Wu, Hai-Chen; Massey, Andrew and Karran, Peter (2004). 4-Thio-5-bromo-2′-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage. Bioorganic and Medicinal Chemistry Letters, 14(4) pp. 995–997.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.bmcl.2003.11.069
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Abstract

4-Thio-5-bromo-2'-deoxyuridine (3a) is prepared from 5-bromo-2'-deoxyuridine (BrdU) and its key properties are explored. The thionucleoside (3a) can react readily with monobromobimane and produces high fluorescence. 3a has UV maximum absorption at 340 nm and can be incorporated into cellular DNA. The cells containing 3a become sensitive to UVA light, offering therapeutic potential for UVA-induced cell killing.

Item Type: Journal Article
ISSN: 0960-894X
Extra Information: Some of the symbols may not have transferred correctly into this bibliographic record and/or abstract.
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3835
Depositing User: Yao Xu
Date Deposited: 06 Jul 2006
Last Modified: 10 Mar 2014 09:32
URI: http://oro.open.ac.uk/id/eprint/3835
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