The Open UniversitySkip to content
 

Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Zhang, Xiaohui; Wang, Jian and Xu, Yao-Zhong (2013). Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides. Magnetic Resonance in Chemistry, 51(9) pp. 523–529.

Full text available as:
Full text not publicly available (Version of Record)
Due to publisher licensing restrictions, this file is not available for public download
Click here to request a copy from the OU Author.
URL: http://onlinelibrary.wiley.com/doi/10.1002/mrc.398...
DOI (Digital Object Identifier) Link: https://doi.org/10.1002/mrc.3980
Google Scholar: Look up in Google Scholar

Abstract

Unambiguous characterization of 5-substituted-4-thiopyrimidine nucleosides (ribonucleosides and 2'-deoxynucleosides) was performed using NMR spectroscopy. Assignments of all proton and carbon signals of 5-bromo-4-thiouridine and related nucleosides were systematically carried out and firmly established by COSY and HMQC techniques. The NMR data of various 4-thiopyrimidine nucleosides are compared, and the key contributing factors discussed. The approach presented here is applicable to other modified nucleosides and nucleotides, as well as nucleobases.

Item Type: Journal Item
Copyright Holders: 2013 John Wiley & Sons
ISSN: 0749-1581
Keywords: NMR; 1H; 13C; 5-substituted pyrimidine; 4-thiothymidine; 4-thiouridine; 5-bromo-4-thiouridine; nucleoside; DNA; RNA
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 38155
Depositing User: Yao Xu
Date Deposited: 13 Aug 2013 08:30
Last Modified: 08 Dec 2018 04:03
URI: http://oro.open.ac.uk/id/eprint/38155
Share this page:

Metrics

Altmetrics from Altmetric

Citations from Dimensions

Actions (login may be required)

Policies | Disclaimer

© The Open University   contact the OU