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Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis

Allman, Sarah A.; Jensen, Henrik H.; Vijayakrishnan, Balakumar; Garnett, James A.; Leon, Ester; Liu, Yan; Anthony, Daniel C.; Sibson, Nicola R.; Feizi, Ten; Matthews, Stephen and Davis, Benjamin G. (2009). Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis. ChemBioChem, 10(15) pp. 2522–2529.

DOI (Digital Object Identifier) Link: https://doi.org/10.1002/cbic.200900425
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Abstract

Unnatural, NMR- and MRI-active fluorinated sugar probes, designed and synthesised to bind to the pathogenic protein TgMIC1 from Toxoplasma gondii, were found to display binding potency equal to and above that of the natural ligand. Dissection of the binding mechanism and modes, including the first X-ray crystal structures of a fluoro-oligosaccharide bound to a lectin, demonstrate that it is possible to create effective fluorinated probe ligands for the study of, and perhaps intervention in, sugar-protein binding events.

Item Type: Journal Item
Copyright Holders: 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN: 1439-7633
Keywords: fluorine; fluorosugars; lectins; oligosaccharides; toxoplasmosis
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 38120
Depositing User: Sarah Allman
Date Deposited: 07 Aug 2013 12:09
Last Modified: 07 Dec 2018 10:17
URI: http://oro.open.ac.uk/id/eprint/38120
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