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Magnetic resonance imaging (MRI) contrast agents that target the brain

O'Connell, Patrick J.; Bruce, James I. and Mortimer, Michael (2005). Magnetic resonance imaging (MRI) contrast agents that target the brain. In: American Chemical Society (ACS) National meeting, 28 Aug - 1 Sept 2005, Washington DC, USA.

URL: http://oasys2.confex.com/acs/230nm/techprogram/P87...
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Abstract

Currently available commercial contrast agents do not cross an intact blood brain barrier (BBB) and are therefore only clinically useful when the BBB is disrupted due to disease. The aim of this project is to synthesise a gadolinium complex that may cross an intact BBB and enable imaging of the brain before a diseased state (eg tumour) has reached an advanced stage and consequently difficult to treat. Once the core ligand has been synthesised, it can be linked to a molecule, R, which promotes transport across the BBB. This ligand can then be reacted with gadolinium chloride to produce a charge-neutral, heptadentate complex. The ability of the complex to enhance the MRI signal can be determined by performing water relaxivity measurements. Its ability to cross the BBB can be estimated by performing octanol-water partitioning measurements. This poster describes the synthesis of the above contrast agents and measurements performed on them.

Item Type: Conference Item
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)
Biomedical Research Network (BRN)
Item ID: 3812
Depositing User: James Bruce
Date Deposited: 30 Jun 2006
Last Modified: 07 Mar 2014 13:46
URI: http://oro.open.ac.uk/id/eprint/3812
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