The Open UniversitySkip to content
 

Chemical Genetics

Shuker, David E.G. (2004). Chemical Genetics. Annual Reports on the Progress of Chemistry, Section B: Organic Chemistry, 100 pp. 191–205.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1039/b401750c
Google Scholar: Look up in Google Scholar

Abstract

Chemical genetics is based on the ability of small molecules to bind reversibly to biological molecules resulting in a phenotypic change in cells. Recent advances in the synthesis of combinatorial libraries of diverse skeletal structure along with the use of cell-based high throughput screening has led to the identification of novel molecules highly targeted towards specific pathways. Screening of pharmaceutical libraries has revealed novel and unexpected combinations of molecules effective against cancer and other diseases. The number of possible molecules less than 3000 daltons is truly vast and it is with chemical genetics that chemical space can be fully explored.

Item Type: Journal Article
ISSN: 0069-3030
Keywords: chemical genetics; diversity-oriented synthesis
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Item ID: 3810
Depositing User: David Shuker
Date Deposited: 30 Jun 2006
Last Modified: 02 Dec 2010 19:50
URI: http://oro.open.ac.uk/id/eprint/3810
Share this page:

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk