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Chemical Genetics

Shuker, David E.G. (2004). Chemical Genetics. Annual Reports on the Progress of Chemistry, Section B: Organic Chemistry, 100 pp. 191–205.

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Chemical genetics is based on the ability of small molecules to bind reversibly to biological molecules resulting in a phenotypic change in cells. Recent advances in the synthesis of combinatorial libraries of diverse skeletal structure along with the use of cell-based high throughput screening has led to the identification of novel molecules highly targeted towards specific pathways. Screening of pharmaceutical libraries has revealed novel and unexpected combinations of molecules effective against cancer and other diseases. The number of possible molecules less than 3000 daltons is truly vast and it is with chemical genetics that chemical space can be fully explored.

Item Type: Journal Item
ISSN: 0069-3030
Keywords: chemical genetics; diversity-oriented synthesis
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 3810
Depositing User: David Shuker
Date Deposited: 30 Jun 2006
Last Modified: 02 May 2018 12:35
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