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Engineered neural tissue for peripheral nerve repair

Georgiou, Melanie; Bunting, Stephen C. J.; Davies, Heather A.; Loughlin, Alison J.; Golding, Jonathan P. and Phillips, James B. (2013). Engineered neural tissue for peripheral nerve repair. Biomaterials, 34(30) pp. 7335–7343.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.biomaterials.2013.06.025
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Abstract

A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. Sheets of this engineered neural tissue supported and directed neuronal growth in a co-culture model, and initial in vivo tests showed that a device containing rods of rolled-up sheets could support neuronal growth during rat sciatic nerve repair (5 mm gap). Further testing of this device for repair of a critical-sized 15 mm gap showed that, at 8 weeks, engineered neural tissue had supported robust neuronal regeneration across the gap. This is, therefore, a useful new approach for generating anisotropic engineered tissues, and it can be used with Schwann cells to fabricate artificial neural tissue for peripheral nerve repair.

Item Type: Article
Copyright Holders: 2013 Elsevier Ltd.
ISSN: 1878-5905
Keywords: collagen; Schwann cell; nerve guide; nerve regeneration; nerve tissue engineering; hydrogel
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
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Item ID: 37977
Depositing User: James Phillips
Date Deposited: 09 Jul 2013 08:06
Last Modified: 01 Feb 2017 06:49
URI: http://oro.open.ac.uk/id/eprint/37977
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