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The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Aβ and acts as a cognitive enhancer

Mileusnic, R.; Lancashire, C.L. and Rose, S.P.R. (2004). The peptide sequence Arg-Glu-Arg, present in the amyloid precursor protein, protects against memory loss caused by Aβ and acts as a cognitive enhancer. European Journal of Neuroscience, 19(7) pp. 1933–1938.

URL: http://www.open.ac.uk/science/biosci/research/inde...
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1111/j.1460-9568.2004.03276.x
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Abstract

Amino acid sequences containing the palindromic tripeptide RER, matching amino acids 328-330 of the amyloid precursor protein APP, when injected intracerebrally prior to or just after training, protect against memory loss induced by amyloid-beta (Aβ) in a one-trial passive avoidance task in the young chick. RER also acts as a cognitive enhancer, strengthening memory for a weak version of the task. N-terminal acylation of RER protects it against rapid degradation, and Ac-RER is effective in restoring memory if administered peripherally. Biotinylated RER binds to chick neuronal perikarya in an APP-displaceable manner via 66 and ~110 kDa neuronal cell membrane proteins. We suggest that RER binding is likely to exert effects on memory retention via receptor-mediated events that include activation of second messenger pathways. These findings suggest that RER and its derivatives may offer a novel approach to enhancing the neuroprotective effects of APP and alleviating the effects of memory loss in the early stages of Alzheimer’s disease.

Item Type: Journal Article
ISSN: 1460-9568
Extra Information: Some of the symbols may not have transferred correctly into this bibliographic record.
Keywords: Amyloid beta; Alzheimer's disease; memory; peptides; therapeutics
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3775
Depositing User: Radmila Mileusnic
Date Deposited: 30 Jun 2006
Last Modified: 10 Mar 2014 10:30
URI: http://oro.open.ac.uk/id/eprint/3775
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