Alberts, Rudi; Fu, Jingyuan; Swertz, Morris A.; Lubbers, L. Alrik; Albers, Casper J. and Jansen, Ritsert C.
(2005).
Combining microarrays and genetic analysis.
Briefings in Bioinformatics, 6(2),
pp. 135–145.
Abstract
Gene expression can be studied at a genome-wide scale with the aid of modern microarray technologies. Expression profiling of tens to hundreds of individuals in a genetic population can reveal the consequences of genetic variation. In this paper it is argued that the design and analysis of such a study is not a matter of simply applying the existing and more-or-less standard computational tools for microarrays to a new type of experimental data. It is shown how to fully exploit the power of genetics through optimal experimental design and analysis for two major microarray technologies, cDNA two-colour arrays and Affymetrix short oligonucleotide arrays.
| Item Type: |
Journal Article
|
| ISSN: |
1477-4054 |
| Extra Information: |
microarray; gene expression; quantitative trait locus; QTL; two-colour microarray; oligonucleotide microarray |
| Academic Unit/Department: |
Mathematics, Computing and Technology |
| Item ID: |
3766 |
| Depositing User: |
Casper Albers
|
| Date Deposited: |
30 Jun 2006 |
| Last Modified: |
02 Dec 2010 19:50 |
| URI: |
http://oro.open.ac.uk/id/eprint/3766 |
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