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Cellular changes in the enteric nervous system during ageing

Saffrey, M. Jill (2013). Cellular changes in the enteric nervous system during ageing. Developmental Biology, 382(1) pp. 344–355.

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The intrinsic neurons of the gut, enteric neurons, have an essential role in gastrointestinal functions. The enteric nervous system is plastic and continues to undergo changes throughout life, as the gut grows and responds to dietary and other environmental changes. Detailed analysis of changes in the ENS during ageing suggests that enteric neurons are more vulnerable to age-related degeneration and cell death than neurons in other parts of the nervous system, although there is considerable variation in the extent and time course of age-related enteric neuronal loss reported in different studies. Specific neuronal subpopulations, particularly cholinergic myenteric neurons, may be more vulnerable than others to age-associated loss or damage. Enteric degeneration and other age-related neuronal changes may contribute to gastrointestinal dysfunction that is common in the elderly population. Evidence suggests that caloric restriction protects against age-associated loss of enteric neurons, but recent advances in the understanding of the effects of the microbiota and the complex interactions between enteric ganglion cells, mucosal immune system and intestinal epithelium indicate that other factors may well influence ageing of enteric neurons. Much remains to be understood about the mechanisms of neuronal loss and damage in the gut, although there is evidence that reactive oxygen species, neurotrophic factor dysregulation and/or activation of a senescence associated phenotype may be involved. To date, there is no evidence for ongoing neurogenesis that might replace dying neurons in the ageing gut, although small local sites of neurogenesis would be difficult to detect. Finally, despite the considerable evidence for enteric neurodegeneration during ageing, and evidence for some physiological changes in animal models, the ageing gut appears to maintain its function remarkably well in animals that exhibit major neuronal loss, indicating that the ENS has considerable functional reserve.

Item Type: Journal Item
Copyright Holders: 2013 Elsevier Inc.
ISSN: 1095-564X
Project Funding Details:
Funded Project NameProject IDFunding Body
Not Set108/SAGSAG10013BBSRC (Biotechnology and Biological Sciences Research Council)
Integrated analysis of the impact of age-associated neuronal and enteroendocrine changes on normal bowel functionsBB/G015988/1BBSRC (Biotechnology and Biological Sciences Research Council)
Keywords: neurodegeneration; caloric restriction; microbiota inflammation; gut–brain axis; oxidative stress; cell senescence; neurotrophic factors; enteric nervous system
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
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Item ID: 37537
Depositing User: Jill Saffrey
Date Deposited: 02 May 2013 08:16
Last Modified: 07 Dec 2018 10:15
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