Hill, Roger R.; Moore, Sharon A. and Roberts, David R.
PDF (Not Set)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1562/2005-04-29-RA-507|
|Google Scholar:||Look up in Google Scholar|
The scope of photobiological processes that involve absorbers within a protein matrix may be limited by the vulnerability of the peptide group to attack by highly reactive redox centers consequent upon electronic excitation. We have explored the nature of this vulnerability by undertaking comprehensive product analyses of aqueous photolysates of 12 N-p-toluene-sulfonyl peptides with systematically selected structures. The results indicate that degradation includes a major pathway that is initiated by intramolecular electron transfer in which the peptide bond serves as electron donor, and the data support the likelihood of a relay process in dipeptide derivatives.
|Item Type:||Journal Article|
|Keywords:||alpha-amino-acids; cleavage reactions; distance dependence; Alzheimers disease; protecting groups; aqueous alkali; oxidation; sulfonamides; mechanism; photodegradation|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Depositing User:||David Roberts|
|Date Deposited:||24 Nov 2006|
|Last Modified:||23 Feb 2016 21:54|
|Share this page:|
► Automated document suggestions from open access sources
Download history for this item
These details should be considered as only a guide to the number of downloads performed manually. Algorithmic methods have been applied in an attempt to remove automated downloads from the displayed statistics but no guarantee can be made as to the accuracy of the figures.