Cummings, Damian M.; Milner, Austen J.; Dallerac, Glenn M.; Vatsavayai, Sarat C.; Brown, Jackie Y.; Waights, Verina; Hirst, Mark C. and Murphy, Kerry P. S. J.
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Huntingdon's disease (HD) is a fatal genetic brain disorder. Predictive genetic testing has revealed early cognitive deficits in asymptomatic patients, in particular impairment in recognition memory. The perirhinal cortex is involved in recognition memory and activity-dependent decrements in neuronal firing are believed to underlie this cognitive process.
In this study, the R6/1 (CAG115) mouse model of HD was used to study changes in perirhinal synaptic plasticity. Brain slices were prepared according to UK legislation. Field potentials were recorded from layer 11/111 in response to stimulation of layer 1 .....[continues].
|Item Type:||Conference Item|
|Academic Unit/Department:||Health and Social Care > Nursing
Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Kerry Murphy|
|Date Deposited:||05 Sep 2006|
|Last Modified:||07 Mar 2014 14:00|
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