Dommett, Eleanor J. and Rostron, Claire L.
|DOI (Digital Object Identifier) Link:||http://doi.org/10.1016/j.bbr.2012.10.025|
|Google Scholar:||Look up in Google Scholar|
The spontaneously hypertensive rat (SHR) is one proposed animal model of attention deficit hyperactivity disorder (ADHD) argued to show strong face validity on the basis of behavioural characteristics. However, SHR may have fundamental alterations to the sensitivity of fluid reward due to altered renal function that has the potential to affect performance in complex reinforced behavioural tests. This could particularly confound determination of operant motivational alterations in the SHR. We assessed baseline bodyweight, home cage lab chow and water intake in the SHR and their typical control strains: Wistar and Wistar Kyoto. We also assessed sucrose preference, and appetitive and consummative positive and negative contrast for sucrose (4% versus 20%) on a motivational runway. As expected, SHR showed enhanced water intake compared to Wistar and Wistar Kyotos but comparable lab chow intake at baseline. SHR exhibited sucrose preference for 4% and 20%, as did both control strains, but the preference for 4% was enhanced in the SHR. SHR showed significant negative and positive contrast in sucrose consumption on the runway, as did Wistar Kyotos. Wistars exhibited neither. Appetitive contrast was not measurable in the SHR due to a robust locomotor velocity increase at the age of testing. The enhanced fluid intake found in the SHR argues against using fluid reinforcers in behavioural tests. We suggest the presence of both forms of contrast in the SHR is unusual for rats tested in ad lib. food conditions while the contrast pattern in Wistars indicate abnormalities in reward sensitivity in this control strain.
|Item Type:||Journal Article|
|Copyright Holders:||2012 Elsevier B.V.|
|Keywords:||reward; SHR; ADHD; dopamine; motivation; drinking|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Ellie Dommett|
|Date Deposited:||05 Dec 2012 10:52|
|Last Modified:||18 Jan 2016 16:06|
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