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Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex

Gabbott, P.L.A.; Warner, T.A. and Busby, S.J. (2006). Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex. Neuroscience, 139(3) pp. 1039–1048.

URL: http://www.sciencedirect.com/science?_ob=ArticleUR...
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.neuroscience.2006.01.026
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Abstract

The projection from the basolateral nucleus of the amygdala (BLA) conveys information about the affective significance of sensory stimuli to the medial prefrontal cortex (mPFC). By using an anterograde tract-tracing procedure combined with immunocytochemistry and correlated light/electron microscopical examination, labeled BLA afferents to layers 2-6 of the rat mPFC are shown to establish asymmetrical synaptic contacts, not only with dendritic spines (approximately 95.7% of targets innervated), but also with the aspiny dendritic shafts and somata of multipolar parvalbumin immunopositive (PV+) neurons. A population of PV- dendritic shafts was also innervated. Labeled BLA synaptic input to identified PV+ structures occurred in layers 2-6 of mPFC. The results indicate that labeled BLA afferents predominantly contact the spiny processes of presumed pyramidal cells and also provide a direct and specific innervation to a sub-population of local circuit neurons in mPFC containing PV. Since PV+ cells include two significant classes of fast-spiking GABAergic inhibitory interneuron (basket and axo-axonic cells), these novel observations indicate that the amygdalocortical pathway in the rat has the ability to directly influence functionally strategic 'feed-forward' inhibitory mechanisms at the first stage of processing amygdalocortical information.

Item Type: Journal Article
ISSN: 0306-4522
Keywords: amygdalocortical afferents; local circuit neurons; disynaptic GABAegic feed-forward inhibition; pyramidal cell activity
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3531
Depositing User: Paul Gabbott
Date Deposited: 11 Aug 2006
Last Modified: 10 Mar 2014 09:26
URI: http://oro.open.ac.uk/id/eprint/3531
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