The Open UniversitySkip to content
 

Differences in the laminar origin of projections from the medial prefrontal cortex to the nucleus accumbens shell and core regions in the rat

Ding, C.D. Ding; Gabbott, Paul L.A. and Totterdell, Susan (2001). Differences in the laminar origin of projections from the medial prefrontal cortex to the nucleus accumbens shell and core regions in the rat. Brain Research, 917(1) pp. 81–89.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S0006-8993(01)02912-2
Google Scholar: Look up in Google Scholar

Abstract

The medial prefrontal cortex (mPFC) projects to the nucleus accumbens shell, core and rostral pole. In this retrograde tract-tracing study of rat mPFC to nucleus accumbens projection neurons, the advantages of Neurobiotin are utilised in order to reveal the detailed morphology of labelled projection cells, and to permit an examination of the laminar projections to shell and core compartments The retrogradely transported Neurobiotin was found in somata, proximal and distal dendrites of neurons that project from the mPFC to the nucleus accumbens. The morphology of these projection neurons was revealed in great detail and confirmed that the projection arises wholly from pyramidal cells. Interestingly, it was also found that retrogradely labelled neurons were exclusively located in prelimbic and infralimbic regions in layers V and VI, after shell injections, but also in layer II following core sites. This observation may reflect possibly different roles for cortical laminae on the nucleus accumbens.

Item Type: Journal Article
Keywords: Prefrontal cortex; Projection neuron; Neurobiotin; Nucleus accumbens
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3511
Depositing User: Paul Gabbott
Date Deposited: 27 Jun 2006
Last Modified: 10 Mar 2014 09:26
URI: http://oro.open.ac.uk/id/eprint/3511
Share this page:

Altmetrics

Scopus Citations

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk