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Atrial cardiomyocyte calcium signalling

Bootman, Martin D.; Smyrnias, Ioannis; Thul, Rüdiger; Coombes, Stephen and Roderick, H. Llewelyn (2011). Atrial cardiomyocyte calcium signalling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1813(5) pp. 922–34.

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DOI (Digital Object Identifier) Link: https://doi.org/10.1016/j.bbamcr.2011.01.030
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Abstract

Whereas Ca2+ signalling in ventricular cardiomyocytes is well described, much less is known regarding the Ca2+ signals within atrial cells. This is surprising given that atrial cardiomyocytes make an important contribution to the refilling of ventricles with blood, which enhances the subsequent ejection of blood from the heart. The dependence of cardiac function on the contribution of atria becomes increasingly important with age and exercise. Disruption of the rhythmic beating of atrial cardiomyocytes can lead to life-threatening conditions such as atrial fibrillation. Atrial and ventricular myocytes have many structural and functional similarities. However, one key structural difference, the lack of transverse tubules ("T-tubules") in atrial myocytes, make these two cell types display vastly different calcium patterns in response to electrical excitation. The lack of T-tubules in atrial myocytes means that depolarisation provokes calcium signals that originate around the periphery of the cells. Under resting conditions, such Ca2+ signals do not propagate towards the centre of the atrial cells and so do not fully engage the contractile machinery. Consequently, contraction of atrial myocytes under resting conditions is modest. However, when atrial myocytes are stimulated with a positive inotropic agonist, such as isoproterenol, the peripheral Ca2+ signals trigger a global wave of Ca2+ that propagates in a centripetal manner into the cells. Enhanced centripetal movement of Ca2+ in atrial myocytes leads to increased contraction and a more substantial contribution to blood pumping.

Item Type: Journal Article
Copyright Holders: 2011 Elsevier B.V.
ISSN: 0167-4889
Extra Information: Including the Special Section: 11th European Symposium on Calcium
Keywords: cardiac; calcium; arrhythmia; signalling; atrial; ryanodine; inositol; inotropy; excitation–contraction coupling; T-tubules
Academic Unit/Department: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 35105
Depositing User: Martin Bootman
Date Deposited: 16 Nov 2012 11:17
Last Modified: 06 Oct 2016 23:31
URI: http://oro.open.ac.uk/id/eprint/35105
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