Calcium regulation in tissue-cultured human and bovine lens epithelial cells

Duncan, G.; Webb, S. F.; Dawson, A. P.; Bootman, M. D. and Elliott, A. J. (1993). Calcium regulation in tissue-cultured human and bovine lens epithelial cells. Investigative Ophthalmology & Visual Science, 34(10) pp. 2835–2842.

Abstract

Lens cytoplasmic calcium is controlled by calcium adenosine triphosphatases at the plasma and endoplasmic reticulum membranes. The former is inhibited by W7 and insensitive to thapsigargin whereas the latter is inhibited by thapsigargin, but insensitive to W7. The lens endoplasmic reticulum store is also controlled by an inositol (1,4,5) trisphosphate calcium-release mechanism. Na+/Ca2+ exchange plays a relatively minor role in calcium regulation, at least at resting calcium levels.

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About

• Item ORO ID
• 35062
• Item Type
• Journal Item
• ISSN
• 1552-5783
• Keywords
• lens: calcium; human; endoplasmic reticulum; Ca ATPase
• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 1993 Association for Research in Vision and Ophthalmology
• Depositing User
• Martin Bootman