Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate

Bello, Davide; Aslam, Tashfeen; Bultynck, Geert; Slawin, Alexandra M. Z.; Roderick, H. Llewelyn; Bootman, Martin D. and Conway, Stuart J. (2007). Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate. The Journal of Organic Chemistry, 72(15) pp. 5647–5659.

DOI: https://doi.org/10.1021/jo070611a

Abstract

The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not act as D-myo-inositol 1,4,5-trisphosphate receptor agonists or antagonists.

Viewing alternatives

Metrics

Item Actions

Export

You can export this page using these formats Digital Object Identifier - DOI

About

• Item ORO ID
• 34876
• Item Type
• Journal Item
• ISSN
• 1520-6904
• Project Funding Details

• Funded Project Name	Project ID	Funding Body
  Not Set	BB/C515255/1	BBSRC (Biotechnology and Biological Sciences Research Council)
  Not Set	Not Set	University of St Andrews

• Academic Unit or School
• Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
  Faculty of Science, Technology, Engineering and Mathematics (STEM)
• Copyright Holders
• © 2007 American Chemical Society
• Depositing User
• Martin Bootman