Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors?

Bootman, Martin D. and Roderick, H. Llewelyn (2008). Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors? American Journal of Physiology. Heart and Circulatory Physiology, 294(2), H579-H581.

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DOI (Digital Object Identifier) Link:	http://dx.doi.org/doi:10.1152/ajpheart.01378.2007
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Abstract

The sequence of events leading to a Ca²⁺ signal during cardiac excitation-contraction (EC) coupling is well known. With each beat, the propagating action potential depolarizes the sarcolemma of the excitable myocytes within the heart. Membrane depolarization leads to the activation of voltage-operated Ca²⁺ channels (VOCs), thereby causing a brief influx of Ca²⁺. The Ca²⁺ influx is sensed and amplified by Ca²⁺ release channels known as ryanodine receptors (RyRs), which are expressed on the sarcoplasmic reticulum (SR) in close apposition to the VOCs. The RyRs are activated by the Ca²⁺ permeating across the VOCs via a process known as Ca²⁺-induced Ca²⁺ release (CICR).

Item Type:	Journal Article
Copyright Holders:	2008 American Physiological Society
ISSN:	0363-6135
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	34873
Depositing User:	Martin Bootman
Date Deposited:	24 Oct 2012 12:40
Last Modified:	24 Oct 2012 20:47
URI:	http://oro.open.ac.uk/id/eprint/34873

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