Bootman, Martin D. and Roderick, H. Llewelyn
Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors?
American Journal of Physiology. Heart and Circulatory Physiology, 294(2) H579-H581.
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The sequence of events leading to a Ca2+ signal during cardiac excitation-contraction (EC) coupling is well known. With each beat, the propagating action potential depolarizes the sarcolemma of the excitable myocytes within the heart. Membrane depolarization leads to the activation of voltage-operated Ca2+ channels (VOCs), thereby causing a brief influx of Ca2+. The Ca2+ influx is sensed and amplified by Ca2+ release channels known as ryanodine receptors (RyRs), which are expressed on the sarcoplasmic reticulum (SR) in close apposition to the VOCs. The RyRs are activated by the Ca2+ permeating across the VOCs via a process known as Ca2+-induced Ca2+ release (CICR).
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