Calcium oscillations

Thul, Ruediger; Bellamy, Tomas C.; Roderick, H. Llewelyn; Bootman, Martin and Coombes, Stephen (2008). Calcium oscillations. Advances in experimental medicine and biology, 641 pp. 1–27.

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DOI (Digital Object Identifier) Link:	http://dx.doi.org/doi:10.1007/978-0-387-09794-7_1
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Abstract

Changes in cellular Ca²⁺ concentration control a wide range of physiological processes, from the subsecond release of synaptic neurotransmitters, to the regulation of gene expression over months or years. Ca²⁺ can also trigger cell death through both apoptosis and necrosis, and so the regulation of cellular Ca²⁺ concentration must be tightly controlled through the concerted action of pumps, channels and buffers that transport Ca²⁺ into and out of the cell cytoplasm. A hallmark of cellular Ca²⁺ signalling is its spatiotemporal complexity: stimulation of cells by a hormone or neurotransmitter leads to oscillations in cytoplasmic Ca²⁺ concentration that can vary markedly in time course, amplitude, frequency, and spatial range.

In this chapter we review some of the biological roles of Ca²⁺, the experimental characterisation of complex dynamic changes in Ca²⁺ concentration, and attempts to explain this complexity using computational models. We consider the 'toolkit' of cellular proteins which influence Ca²⁺ concentrarion, describe mechanistic models of key elements of the toolkit, and fit these into the framework of whole cell models of Ca²⁺ oscillations and waves. Finally, we will touch on recent efforts to use stochastic modelling to elucidate elementary Ca²⁺ signal events, and how these may evolve into global signals.

Item Type:	Journal Article
Copyright Holders:	008 Landes Bioscience and Springer Science+Business Media, LLC
ISSN:	0065-2598
Extra Information:	Cellular Oscillatory Mechanisms Edited by Miguel Maroto, Nicholas A.M. Monk Landes Bioscience/Springer Science+Business Media, LLC, 2008 ISBN: 978-0-387-09793-0
Keywords:	circadian rhythms; cellular signal transduction; biological rhythms
Academic Unit/Department:	Science > Life, Health and Chemical Sciences
Item ID:	34865
Depositing User:	Martin Bootman
Date Deposited:	24 Oct 2012 12:19
Last Modified:	24 Oct 2012 13:22
URI:	http://oro.open.ac.uk/id/eprint/34865

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