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Calcium oscillations

Thul, Ruediger; Bellamy, Tomas C.; Roderick, H. Llewelyn; Bootman, Martin and Coombes, Stephen (2008). Calcium oscillations. Advances in Experimental Medicine and Biology, 641 pp. 1–27.

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Changes in cellular Ca2+ concentration control a wide range of physiological processes, from the subsecond release of synaptic neurotransmitters, to the regulation of gene expression over months or years. Ca2+ can also trigger cell death through both apoptosis and necrosis, and so the regulation of cellular Ca2+ concentration must be tightly controlled through the concerted action of pumps, channels and buffers that transport Ca2+ into and out of the cell cytoplasm. A hallmark of cellular Ca2+ signalling is its spatiotemporal complexity: stimulation of cells by a hormone or neurotransmitter leads to oscillations in cytoplasmic Ca2+ concentration that can vary markedly in time course, amplitude, frequency, and spatial range.

In this chapter we review some of the biological roles of Ca2+, the experimental characterisation of complex dynamic changes in Ca2+ concentration, and attempts to explain this complexity using computational models. We consider the 'toolkit' of cellular proteins which influence Ca2+ concentrarion, describe mechanistic models of key elements of the toolkit, and fit these into the framework of whole cell models of Ca2+ oscillations and waves. Finally, we will touch on recent efforts to use stochastic modelling to elucidate elementary Ca2+ signal events, and how these may evolve into global signals.

Item Type: Journal Item
Copyright Holders: 008 Landes Bioscience and Springer Science+Business Media, LLC
ISSN: 0065-2598
Extra Information: Cellular Oscillatory Mechanisms
Edited by Miguel Maroto, Nicholas A.M. Monk
Landes Bioscience/Springer Science+Business Media, LLC, 2008
ISBN: 978-0-387-09793-0
Keywords: circadian rhythms; cellular signal transduction; biological rhythms
Academic Unit/School: Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Item ID: 34865
Depositing User: Martin Bootman
Date Deposited: 24 Oct 2012 12:19
Last Modified: 02 May 2018 13:45
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