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An update on nuclear calcium signalling

Bootman, Martin D.; Fearnley, Claire; Smyrnias, Ioannis; MacDonald, Fraser and Roderick, H. Llewelyn (2009). An update on nuclear calcium signalling. Journal of Cell Science, 122 pp. 2337–2350.

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Abstract

Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this Commentary, we describe mechanisms of nuclear Ca2+ signalling and discuss what is known about the origin and physiological significance of nuclear Ca2+ transients. In particular, we focus on the idea that the nucleus has an autonomous Ca2+ signalling system that can generate its own Ca2+ transients that modulate processes such as gene transcription. We also discuss the role of nuclear pores and the nuclear envelope in controlling ion flux into the nucleoplasm.

Item Type: Journal Article
Copyright Holders: 2009 The Company of Biologists Limited
ISSN: 1477-9137
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 34861
Depositing User: Martin Bootman
Date Deposited: 25 Oct 2012 10:39
Last Modified: 07 Mar 2014 19:27
URI: http://oro.open.ac.uk/id/eprint/34861
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