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Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca2+ signaling and disease

Distelhorst, Clark W. and Bootman, Martin D. (2011). Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca2+ signaling and disease. Cell Calcium, 50(3) pp. 234–41.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/j.ceca.2011.05.011
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Abstract

The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel to regulate IP3-mediated Ca2+ release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and also its homologue Bcl-xl, with the IP3R and how these interactions regulate Ca2+ signaling. The dual role of these interactions in promoting prosurvival Ca2+ signals, while at the same time inhibiting proapoptotic Ca2+ signals, is discussed. Moreover, this review will elucidate the recently recognized importance of the Bcl-2-IP3R interaction in human disease.

Item Type: Journal Article
Copyright Holders: 2011 Elsevier
ISSN: 1532-1991
Keywords: calcium; inositol 1,4,5-trisphosphate receptor; Bcl-2; Bcl-xl; apoptosis; chronic lymphocytic leukemia; bipolar disorder
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Related URLs:
Item ID: 34837
Depositing User: Martin Bootman
Date Deposited: 25 Oct 2012 09:05
Last Modified: 07 Mar 2014 15:03
URI: http://oro.open.ac.uk/id/eprint/34837
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