Distelhorst, Clark W. and Bootman, Martin D.
|DOI (Digital Object Identifier) Link:||http://dx.doi.org/10.1016/j.ceca.2011.05.011|
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The Bcl-2 protein, best known for its ability to inhibit apoptosis, interacts with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel to regulate IP3-mediated Ca2+ release from the endoplasmic reticulum. This review summarizes the current state of knowledge regarding the interaction of Bcl-2, and also its homologue Bcl-xl, with the IP3R and how these interactions regulate Ca2+ signaling. The dual role of these interactions in promoting prosurvival Ca2+ signals, while at the same time inhibiting proapoptotic Ca2+ signals, is discussed. Moreover, this review will elucidate the recently recognized importance of the Bcl-2-IP3R interaction in human disease.
|Item Type:||Journal Article|
|Copyright Holders:||2011 Elsevier|
|Keywords:||calcium; inositol 1,4,5-trisphosphate receptor; Bcl-2; Bcl-xl; apoptosis; chronic lymphocytic leukemia; bipolar disorder|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences
|Interdisciplinary Research Centre:||Biomedical Research Network (BRN)|
|Depositing User:||Martin Bootman|
|Date Deposited:||25 Oct 2012 09:05|
|Last Modified:||18 Jan 2016 15:48|
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