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Calcium signaling in cardiac myocytes

Fearnley, C. J.; Roderick, H. L. and Bootman, M. D. (2011). Calcium signaling in cardiac myocytes. Cold Spring Harbor perspectives in biology, 3(11) a004242.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1101/cshperspect.a004242
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Abstract

Calcium (Ca(2+)) is a critical regulator of cardiac myocyte function. Principally, Ca(2+) is the link between the electrical signals that pervade the heart and contraction of the myocytes to propel blood. In addition, Ca(2+) controls numerous other myocyte activities, including gene transcription. Cardiac Ca(2+) signaling essentially relies on a few critical molecular players--ryanodine receptors, voltage-operated Ca(2+) channels, and Ca(2+) pumps/transporters. These moieties are responsible for generating Ca(2+) signals upon cellular depolarization, recovery of Ca(2+) signals following cellular contraction, and setting basal conditions. Whereas these are the central players underlying cardiac Ca(2+) fluxes, networks of signaling mechanisms and accessory proteins impart complex regulation on cardiac Ca(2+) signals. Subtle changes in components of the cardiac Ca(2+) signaling machinery, albeit through mutation, disease, or chronic alteration of hemodynamic demand, can have profound consequences for the function and phenotype of myocytes. Here, we discuss mechanisms underlying Ca(2+) signaling in ventricular and atrial myocytes. In particular, we describe the roles and regulation of key participants involved in Ca(2+) signal generation and reversal.

Item Type: Journal Article
Copyright Holders: 2011 Cold Spring Harbour
ISSN: 1943-0264
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 34834
Depositing User: Martin Bootman
Date Deposited: 25 Oct 2012 09:00
Last Modified: 07 Mar 2014 15:03
URI: http://oro.open.ac.uk/id/eprint/34834
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