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Activation of cyclic AMP-dependent protein kinase is required for long-term enhancement at corticostriatal synapses in rats

Spencer, Jonathan P. and Murphy, Kerry P.S.J. (2002). Activation of cyclic AMP-dependent protein kinase is required for long-term enhancement at corticostriatal synapses in rats. Neuroscience Letters, 329(2) pp. 217–221.

DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1016/S0304-3940(02)00659-6
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Abstract

The induction of long-term potentiation (LTP) at corticostriatal synapses is dependent on the activation of postsynaptic NMDA receptors, but the mechanisms involved in the maintenance of LTP are not known. We report here that forskolin, an activator of adenylyl cyclase, induces a lasting enhancement of the corticostriatal synaptic response. This enhancement is associated with a lasting decrease in paired-pulse ratio, and is blocked by inhibitors of adenylyl cyclase and cyclic AMP-dependent protein kinase (PKA), but not by a PKA inhibitor injected into the postsynaptic cell. Tetanically-induced LTP is also associated with a decrease in paired-pulse ratio and partially occludes the subsequent action of forskolin. Our results suggest that activation of presynaptic PKA can enhance neurotransmission at corticostriatal synapses; a mechanism required for the expression of LTP at these synapses. Copyright 2002 Elsevier Science Ireland Ltd.

Item Type: Journal Article
ISSN: 0304-3940
Keywords: Striatum; Long-term potentiation (LTP); Basal ganglia; Forskolin; Protein kinase; Presynaptic; Cyclic AMP; Glutamate
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 3459
Depositing User: Kerry Murphy
Date Deposited: 28 Jun 2006
Last Modified: 07 Mar 2014 14:00
URI: http://oro.open.ac.uk/id/eprint/3459
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