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Kimani, Stanley; Shmigol, Tatiana; Hammond, Samantha; Phillips, James B.; Bruce, James I.; MacRobert, Alexander J.; Malakhov, Mikhail V. and Golding, Jon P.
(2013).
DOI: https://doi.org/10.1111/j.1751-1097.2012.01204.x
Abstract
Phthalocyanine photosensitizers are effective in anticancer photodynamic therapy (PDT) but suffer from limited solubility, limited cellular uptake, and limited selectivity for cancer cells. In order to improve these characteristics, we synthesized isopropylidene-protected and partially deprotected tetra β-glycosylated zinc (II) phthalocyanines and compared their uptake and accumulation kinetics, subcellular localization, in vitro photocytotoxicity, and reactive oxygen species generation to those of disulfonated aluminium phthalocyanine. In MCF-7 cancer cells, one of the compounds, Zinc phthalocyanine , demonstrated ten-fold higher uptake, five-fold greater PDT-induced cellular reactive oxygen species concentration, and two-fold greater phototoxicity than equimolar (9 μM) disulfonated aluminium phthalocyanine. Thus, isopropylidene-protected β-glycosylation of phthalocyanines provides a simple method of improving the efficacy of photodynamic therapy.
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About
- Item ORO ID
- 34098
- Item Type
- Journal Item
- ISSN
- 1751-1097
- Project Funding Details
-
Funded Project Name Project ID Funding Body Not Set Not Set Open University - Academic Unit or School
-
Faculty of Science, Technology, Engineering and Mathematics (STEM)
Faculty of Science, Technology, Engineering and Mathematics (STEM) > Life, Health and Chemical Sciences - Research Group
- Cancer Research Group
- Copyright Holders
- © 2012 Wiley Periodicals, Inc., © 2012 The American Society of Photobiology
- Depositing User
- Jon Golding