The Open UniversitySkip to content
 

Effect of ionizing radiation on the protein-synthesizing system of brain neurons of ground squirrels in different functional states

Gordon, R. Ya.; Ignatyev, D. A.; Mel'nikova, E. V.; Rogachevskii, V. V.; Kraev, I. V. and Khutzian, S. S. (2006). Effect of ionizing radiation on the protein-synthesizing system of brain neurons of ground squirrels in different functional states. Biophysics, 51(2) pp. 270–276.

Full text available as:
Full text not publicly available
Due to copyright restrictions, this file is not available for public download
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0...
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1134/S0006350906020199
Google Scholar: Look up in Google Scholar

Abstract

Using fluorescence and electron microscopy, it is shown that the physiological state of ground squirrels exposed to ionizing radiation at different stages of the torpor-awakeness (hypothermia-normothermia) cycle is the main factor responsible for changes in the protein-synthesizing system of neurons in the hippocampus (fields CA1 and CA3) and the sensomotor cortex. The neurons of animals irradiated in the state of awakeness are less radioresistant and recover more slowly than neurons of animals irradiated in torpor, with the difference being more distinct in neurons of the CA1 field. The effect of irradiation is weak in animals entering torpor and reaches a peak in awakening animals. It is proposed that the inhibition of protein synthesis in the latter case takes place at the elongation stage, with heavy polysomes formed in the cytoplasm of neurons.

Item Type: Journal Article
Copyright Holders: 2006 Pleiades Publishing, Inc.
ISSN: 1555-6654
Extra Information: Original Russian Text © R.Ya. Gordon, D.A. Ignatyev, E.V. Mel’nikova, V.V. Rogachevskii, I.V. Kraev, S.S. Khutzian, 2006, published in Biofizika, 2006, Vol. 51, No. 2,
pp. 316–323
Keywords: heavy polysomes; hibernation; ionizing radiation; neurons; protein-synthesizing system; animalia; sciuridae; spermophilus
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Research in Computing (CRC)
Biomedical Research Network (BRN)
Item ID: 32815
Depositing User: Igor Kraev
Date Deposited: 13 Mar 2012 17:24
Last Modified: 13 Mar 2014 06:14
URI: http://oro.open.ac.uk/id/eprint/32815
Share this page:

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk