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Changes of activity of the protein-synthesizing system of brain neurons of the ground squirrel Citellus undulatus during hibernation and hypothermia

Gordon, R. Ya.; Ignatiev, D. A.; Rogachevskii, V. V.; Medvedev, N. I.; Kraev, I. V.; Patrushev, I. V.; Khutsyan, S. S. and Popov, V. I. (2006). Changes of activity of the protein-synthesizing system of brain neurons of the ground squirrel Citellus undulatus during hibernation and hypothermia. Journal of Evolutionary Biochemistry and Physiology, 42(3) pp. 299–307.

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Using fluorescent and electron microscopy a comparative analysis was performed of components of the protein-synthesizing system of hippocampal neurons both in ground squirrels in various phases of the torpor-activity cycle and in rats cooled under the hypoxia-hypercapnia conditions. Results of the study have shown that in hippocampal neurons of the ground squirrels entering the natural torpor state and of rats under conditions of artificial hypothermia to 17°C, similar mechanisms might be possible to function, one of their obligatory components being a generalized decrease of activity of the protein-synthesizing system with its subsequent restoration at the exit from hypothermia. Cessation of hypoxia-hypercapnia even under conditions of a further temperature decrease restored the rat neuronal protein-synthesizing activity, which seems to indicate the presence of a potential possibility of adaptation of brain neurons in vivo to low temperatures, at which the integral organism of non-hibernating homoeothermic animals does not survive. © 2006 Nauka/Interperiodica.

Item Type: Journal Article
Copyright Holders: 2006 Pleiades Publishing, Inc.
ISSN: 1608-3202
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetRussian Foundation for Basic Research (projects nos. 02-04-48877and 02-04-48890)
Extra Information: Original Russian Text © R. Ya. Gordon, D. A. Ignatiev, V. V. Rogachevskii, N. I. Medvedev, I. V. Kraev, I. V. Patrushev, S. S. Khutsyan, and V. I. Popov, 2006, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2006, Vol. 42, No. 3, pp. 237—243.
Keywords: animalia; citellus undulatus; sciuridae; spermophilus
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Research in Computing (CRC)
Biomedical Research Network (BRN)
Item ID: 32814
Depositing User: Igor Kraev
Date Deposited: 13 Mar 2012 17:12
Last Modified: 26 Feb 2016 13:11
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