Ignat'ev, D. A.; Fialkovskaia, L. A.; Perepelkina, N. I.; Markevich, L. N.; Kraev, I. V. and Kolomiǐtseva, I. K.
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The cooling of Wistar rats up to 15-19 degrees C under a condition hypoxia-hypercapnia increased the radioresistance with a dose reduction factor (DRF) of 1.4. To elucidate the mechanisms of hypothermia radioprotective effect was evaluated the functional state of rat neocortex using a electroencephalogram (EEG) as well as was studied the lipid composition of neocortex under the conditions of both normothermia and hypothermia. At 19-20 degrees C the activity within a wide range of frequencies in EEG was suppressed; the nonregular slow waves were recorded against a background of "silence". The reduction of EEG spectrum with increasing temperature began with the low frequencies. At 26-28 degrees C the contribution of theta-rhythm (an indicator of brain activity level) in EEG reaches the normothermia value, from this point the rat brain starts to functionate as a whole system. At normothermia the similarity of neocortex lipid composition in nonhibernators (rats) and hibernators (ground squirrels) mammalians was noted. The difference is only in a higher content of phosphatidylinositol in rats. Rats falling into hypothermia state as well as ground squirrels into torpor is followed by a decrease of cholesterol content and the absence of significant changes of the phospholipid composition in neocortex tissues.
|Item Type:||Journal Article|
|Copyright Holders:||2006 MAIK Nauka/Interperiodica|
|Extra Information:||Article in Russian|
|Keywords:||cholesterol; lipid, animal; article; body temperature; brain; cryoanesthesia; electroencephalography; heart rate; hibernation; male; metabolism; neocortex; physiology; radiation dose; radiation response; rat; theta rhythm; Wistar rat; X ray, Animals; Body Temperature; Brain; Cholesterol; Dose-Response Relationship, Radiation; Electroencephalography; Heart Rate; Hibernation; Hypothermia, Induced; Lipids; Male; Neocortex; Radiation Tolerance; Rats; Rats, Wistar; Theta Rhythm; X-Rays|
|Academic Unit/Department:||Science > Life, Health and Chemical Sciences|
|Interdisciplinary Research Centre:||Centre for Research in Computing (CRC)
Biomedical Research Network (BRN)
|Depositing User:||Igor Kraev|
|Date Deposited:||15 Mar 2012 13:51|
|Last Modified:||10 Mar 2014 09:34|
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