The effect of hypothermia on the rat radioresistance

Ignat'ev, D. A.; Fialkovskaia, L. A.; Perepelkina, N. I.; Markevich, L. N.; Kraev, I. V. and Kolomiǐtseva, I. K. (2006). The effect of hypothermia on the rat radioresistance. Radiatsionnaia biologiia, radioecologiia, 46(6) pp. 706–712.

Abstract

The cooling of Wistar rats up to 15-19 degrees C under a condition hypoxia-hypercapnia increased the radioresistance with a dose reduction factor (DRF) of 1.4. To elucidate the mechanisms of hypothermia radioprotective effect was evaluated the functional state of rat neocortex using a electroencephalogram (EEG) as well as was studied the lipid composition of neocortex under the conditions of both normothermia and hypothermia. At 19-20 degrees C the activity within a wide range of frequencies in EEG was suppressed; the nonregular slow waves were recorded against a background of "silence". The reduction of EEG spectrum with increasing temperature began with the low frequencies. At 26-28 degrees C the contribution of theta-rhythm (an indicator of brain activity level) in EEG reaches the normothermia value, from this point the rat brain starts to functionate as a whole system. At normothermia the similarity of neocortex lipid composition in nonhibernators (rats) and hibernators (ground squirrels) mammalians was noted. The difference is only in a higher content of phosphatidylinositol in rats. Rats falling into hypothermia state as well as ground squirrels into torpor is followed by a decrease of cholesterol content and the absence of significant changes of the phospholipid composition in neocortex tissues.

Viewing alternatives

Look up in Google Scholar
No digital document available to download for this item

Item Actions

Export

About

  • Item ORO ID
  • 32812
  • Item Type
  • Journal Item
  • ISSN
  • 0869-8031
  • Extra Information
  • Article in Russian
  • Keywords
  • cholesterol; lipid, animal; article; body temperature; brain; cryoanesthesia; electroencephalography; heart rate; hibernation; male; metabolism; neocortex; physiology; radiation dose; radiation response; rat; theta rhythm; Wistar rat; X ray, Animals; Body Temperature; Brain; Cholesterol; Dose-Response Relationship, Radiation; Electroencephalography; Heart Rate; Hibernation; Hypothermia, Induced; Lipids; Male; Neocortex; Radiation Tolerance; Rats; Rats, Wistar; Theta Rhythm; X-Rays
  • Academic Unit or School
  • Faculty of Science, Technology, Engineering and Mathematics (STEM)
  • Research Group
  • Centre for Research in Computing (CRC)
  • Copyright Holders
  • © 2006 MAIK Nauka/Interperiodica
  • Related URLs
  • Depositing User
  • Igor Kraev
CORE (COnnecting REpositories)

Recommendations