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Ignat'ev, D. A.; Fialkovskaia, L. A.; Perepelkina, N. I.; Markevich, L. N.; Kraev, I. V. and Kolomiǐtseva, I. K.
(2006).
Abstract
The cooling of Wistar rats up to 15-19 degrees C under a condition hypoxia-hypercapnia increased the radioresistance with a dose reduction factor (DRF) of 1.4. To elucidate the mechanisms of hypothermia radioprotective effect was evaluated the functional state of rat neocortex using a electroencephalogram (EEG) as well as was studied the lipid composition of neocortex under the conditions of both normothermia and hypothermia. At 19-20 degrees C the activity within a wide range of frequencies in EEG was suppressed; the nonregular slow waves were recorded against a background of "silence". The reduction of EEG spectrum with increasing temperature began with the low frequencies. At 26-28 degrees C the contribution of theta-rhythm (an indicator of brain activity level) in EEG reaches the normothermia value, from this point the rat brain starts to functionate as a whole system. At normothermia the similarity of neocortex lipid composition in nonhibernators (rats) and hibernators (ground squirrels) mammalians was noted. The difference is only in a higher content of phosphatidylinositol in rats. Rats falling into hypothermia state as well as ground squirrels into torpor is followed by a decrease of cholesterol content and the absence of significant changes of the phospholipid composition in neocortex tissues.
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About
- Item ORO ID
- 32812
- Item Type
- Journal Item
- ISSN
- 0869-8031
- Extra Information
- Article in Russian
- Keywords
- cholesterol; lipid, animal; article; body temperature; brain; cryoanesthesia; electroencephalography; heart rate; hibernation; male; metabolism; neocortex; physiology; radiation dose; radiation response; rat; theta rhythm; Wistar rat; X ray, Animals; Body Temperature; Brain; Cholesterol; Dose-Response Relationship, Radiation; Electroencephalography; Heart Rate; Hibernation; Hypothermia, Induced; Lipids; Male; Neocortex; Radiation Tolerance; Rats; Rats, Wistar; Theta Rhythm; X-Rays
- Academic Unit or School
- Faculty of Science, Technology, Engineering and Mathematics (STEM)
- Research Group
- Centre for Research in Computing (CRC)
- Copyright Holders
- © 2006 MAIK Nauka/Interperiodica
- Related URLs
- Depositing User
- Igor Kraev