Ignat'ev, D. A.; Fialkovskaia, L. A.; Perepelkina, N. I.; Markevich, L. N.; Kraev, I. V. and Kolomiǐtseva, I. K.
(2006).
The effect of hypothermia on the rat radioresistance.
Radiatsionnaia biologiia, radioecologiia, 46(6),
pp. 706–712.
Abstract
The cooling of Wistar rats up to 15-19 degrees C under a condition hypoxia-hypercapnia increased the radioresistance with a dose reduction factor (DRF) of 1.4. To elucidate the mechanisms of hypothermia radioprotective effect was evaluated the functional state of rat neocortex using a electroencephalogram (EEG) as well as was studied the lipid composition of neocortex under the conditions of both normothermia and hypothermia. At 19-20 degrees C the activity within a wide range of frequencies in EEG was suppressed; the nonregular slow waves were recorded against a background of "silence". The reduction of EEG spectrum with increasing temperature began with the low frequencies. At 26-28 degrees C the contribution of theta-rhythm (an indicator of brain activity level) in EEG reaches the normothermia value, from this point the rat brain starts to functionate as a whole system. At normothermia the similarity of neocortex lipid composition in nonhibernators (rats) and hibernators (ground squirrels) mammalians was noted. The difference is only in a higher content of phosphatidylinositol in rats. Rats falling into hypothermia state as well as ground squirrels into torpor is followed by a decrease of cholesterol content and the absence of significant changes of the phospholipid composition in neocortex tissues.
| Item Type: |
Journal Article
|
| Copyright Holders: |
2006 MAIK Nauka/Interperiodica |
| ISSN: |
0869-8031 |
| Extra Information: |
Article in Russian |
| Keywords: |
cholesterol; lipid, animal; article; body temperature; brain; cryoanesthesia; electroencephalography; heart rate; hibernation; male; metabolism; neocortex; physiology; radiation dose; radiation response; rat; theta rhythm; Wistar rat; X ray, Animals; Body Temperature; Brain; Cholesterol; Dose-Response Relationship, Radiation; Electroencephalography; Heart Rate; Hibernation; Hypothermia, Induced; Lipids; Male; Neocortex; Radiation Tolerance; Rats; Rats, Wistar; Theta Rhythm; X-Rays |
| Academic Unit/Department: |
Science > Life, Health and Chemical Sciences |
| Interdisciplinary Research Centre: |
Centre for Research in Computing (CRC) |
| Related URLs: |
|
| Item ID: |
32812 |
| Depositing User: |
Igor Kraev
|
| Date Deposited: |
15 Mar 2012 13:51 |
| Last Modified: |
15 Mar 2012 13:51 |
| URI: |
http://oro.open.ac.uk/id/eprint/32812 |
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