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Protective effect of hypothermia on brain neurons in rats exposed to ionizing radiation

Gordon, R. Ya.; Ignat'ev, D. A.; Mel'nikova, E. V.; Rogachevskii, V. V.; Kraev, I. V. and Khutsyan, S. S. (2007). Protective effect of hypothermia on brain neurons in rats exposed to ionizing radiation. Biophysics, 52(3) pp. 344–349.

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The protein-synthesizing system of hippocampal (CA1, CA3) and sensorimotor cortex neurons is damaged less and recovers much quicker in rats exposed to 8 Gy of gamma-radiation under hypoxia/hypercapnia (body temperature 16-18°C) than under usual conditions, as evidenced by microfluorimetry and electron microscopy. The radioprotective effect does not cover the membrane structures (endoplasmic reticulum and Golgi complex), and their restoration is not so prompt.

Item Type: Journal Article
Copyright Holders: 2007 Pleiades Publishing, Inc.
ISSN: 1872-6240
Extra Information: Original Russian Text © R.Ya. Gordon, D.A. Ignat’ev, E.V. Mel’nikova, V.V. Rogachevskii, I.V. Kraev, S.S. Khutsyan, 2007, published in Biofizika, 2007, Vol. 52, No. 3,
pp. 565–571.
Keywords: hypothermia; hypoxia/hypercapnia; ionizing radiation; protein-synthesizing system; Rattus
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Centre for Research in Computing (CRC)
Biomedical Research Network (BRN)
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Item ID: 32811
Depositing User: Igor Kraev
Date Deposited: 12 Mar 2012 10:58
Last Modified: 18 Mar 2014 13:26
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