Santalova, I. M.; Zakharova, N. M.; Khramov, R. N.; Kraev, I. V.; Murashev, A. N.; Averin, A. S. and Fakhranurova, L. I.
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|DOI (Digital Object Identifier) Link:||http://doi.org/10.1134/S0006350908050230|
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Hypertensive SHR rates were irradiated with orange-red light using a Korobkov photon light-emitting diode matrix with a maximum radiation at 612 nm; irradiation was performed daily for 1 h for 13 days. After the course of irradiation, the rhythmoinothropic characteristics of the cardiac papillary muscle significantly improved. Morphological analysis revealed active rearrangement in myocytes, which were observed primarily in the structure of the sarcoplasmic reticulum (SR), whose relative area increased more than twice compared to the control. Apparently, photon therapy of hypertensive rats normalizes calcium homeostasis in myocytes and improves the calcium-transport function of SR. The normalization of structural and functional characteristics of the myocardium with hypertensive rates may result from an increase in the SR buffer capacity and activation of SR Ca2+-ATPase. Furthermore, qualitative and quantitative changes in the proportion of capillaries, myofibrils, and mitochondria in myocytes indicate the development of adaptive-compensatory processes leading to the activation of biosynthetic processes and an increase in the energy potential of the myocardium.
|Item Type:||Journal Article|
|Copyright Holders:||2008 Pleiades Publishing, Inc.|
|Extra Information:||Original Russian Text © I.M. Santalova, N.M. Zakharova, R.N. Khramov, I.V. Kraev, A.N. Murashev, A.S. Averin, L.I. Fakhranurova, 2008, published in Biofizika, 2008, Vol. 53, No. 5, pp. 879–885.|
|Keywords:||force-frequency characteristics of myocardium; orange-red light; regulation of calcium homeostasis; sarcoplasmic reticulum|
|Academic Unit/Department:||Faculty of Science, Technology, Engineering and Mathematics (STEM)|
|Interdisciplinary Research Centre:||Centre for Research in Computing (CRC)
Biomedical Research Network (BRN)
|Depositing User:||Igor Kraev|
|Date Deposited:||22 Feb 2012 16:59|
|Last Modified:||04 Oct 2016 13:56|
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