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Different “weight” of cardiac and general adiposity in predicting left in trouble morphology

Iacobellis, Gianluca; Pond, Caroline M. and Sharma, Arya M. (2006). Different “weight” of cardiac and general adiposity in predicting left in trouble morphology. Obesity, 14(10) pp. 1679–1684.

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DOI (Digital Object Identifier) Link: http://dx.doi.org/10.1038/oby.2006.192
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Abstract

Excess adiposity has been widely related to cardiac morphological changes. Nevertheless, the mechanistic link between increased adiposity and left ventricular (LV) morphology is controversial and not completely understood. In this context, several authors have recently debated the different "weight" of BMI as an index of general adiposity vs. the importance of the epicardial fat depot as a marker of local visceral adiposity in obesity-related LV changes. Studies in uncomplicated obesity suggest that the role of BMI in predicting LV abnormalities remains rather doubtful. In contrast, several lines of evidence suggest that cardiac adiposity could play an important part in the development of cardiac modifications. Epicardial fat as an index of cardiac adiposity could have a functional and mechanical role in obesity-related LV abnormalities. Epicardial fat is clinically correlated with LV mass, atrial dimensions, and diastolic function, but a causal effect of epicardial adipose tissue on cardiac chamber modifications remains to be demonstrated. Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues.

Item Type: Journal Article
Copyright Holders: 2006 NAASO
ISSN: 1930-739X
Keywords: epicardial adipose tissue; epicardial fat; cardiac adiposity; uncomplicated obesity; left ventricle hypertrophy
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 31391
Depositing User: Caroline Pond
Date Deposited: 13 Feb 2012 15:13
Last Modified: 13 Mar 2014 03:15
URI: http://oro.open.ac.uk/id/eprint/31391
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