The Open UniversitySkip to content
 

Age-related biomarkers can be modulated by diet in the rat

MacQueen, Hilary Anne; Wassif, Wassif Samuel; Walker, Ian; Sadler, Dawn Angela and Evans, Karen (2011). Age-related biomarkers can be modulated by diet in the rat. Food and Nutrition Sciences, 2(8) pp. 884–890.

Warning

This is the latest version of this eprint.

Full text available as:
Full text not publicly available
Due to copyright restrictions, this file is not available for public download
Click here to request a copy from the OU Author.
URL: http://www.scirp.org/journal/fns
DOI (Digital Object Identifier) Link: http://dx.doi.org/10.4236/fns.2011.28120
Google Scholar: Look up in Google Scholar

Abstract

This study seeks to establish the normal serum concentrations of biochemical markers related to nutrition, inflammation and disease, and to investigate how the levels change with age and diet in the rat. To this end, we fed rats from weaning on three diets differing in their protein, carbohydrate and fatty acid content. The diets consisted of a control, nutritionally balanced diet, this same diet supplemented with 10% (wt/wt) beef tallow, and a diet that was high in fat and carbohydrate and low in protein. Blood samples from rats at two different ages, 3 months and 12 months, were then analysed. In control rats, with advancing age there was a general decrease in potassium, iron and serum albumin concentrations and in the activities of aspartate aminotransferase and alanine aminotransferase, and an increase in total and HDL cholesterol. These changes were modulated by diet: many of the age-related changes (serum concentrations of potassium, iron and cholesterol, and liver enzyme activities) were not observed in animals eating the high fat diet. In contrast, the high carbohydrate, high fat, low protein diet-fed animals showed several additional changes (serum concentrations of sodium, urea, creatinine and TG, and activity of alkaline phosphatase) that can be related to kidney, liver and cardiovascular health.

Item Type: Journal Article
Copyright Holders: 2011 SciRes
ISSN: 2157-9458
Project Funding Details:
Funded Project NameProject IDFunding Body
Not SetNot SetThe Open University
Keywords: ageing; disease; diet; biomarker; rat
Academic Unit/Department: Science > Life, Health and Chemical Sciences
Science
Interdisciplinary Research Centre: Biomedical Research Network (BRN)
Item ID: 31291
Depositing User: Hilary MacQueen
Date Deposited: 19 Jan 2012 15:40
Last Modified: 07 Mar 2014 19:58
URI: http://oro.open.ac.uk/id/eprint/31291
Share this page:

Available Versions of this Item

Actions (login may be required)

View Item
Report issue / request change

Policies | Disclaimer

© The Open University   + 44 (0)870 333 4340   general-enquiries@open.ac.uk